Neucrine Biosciences (NBIX, news, chart) is seeing bullish order flow. With shares up 20 cents to $4.80, total volume in the options market is running 30 times the usual. 5,500 calls have traded, compared to less than 500 puts. The September 5 calls are the most actives, with 5,000 contracts traded and 99 percent of today’s volume trading offerside. It looks a lot like speculative call buying. Consequently, directional sentiment based on flow in NBIX is 90 percent bullish. The company reported earnings last week and traded to a 52-week low of $4.00 a share on July 3rd. No other news on the wires.